It is important to put yourself in the shoes of the Admissions Officer: why would your personal statement be unique, how are you different from the other candidates? Primarily you need to decide how you will divide your personal statement into digestible chucks. The most obvious way is to divide into paragraphs of 100 words. If you aim for between 500 and 600 words at most, it will help your admission officer when they have to read thousands of personal statements to find the perfect student.
In conceptualizing a theme, you have to consider the main question, "What would you like to say with your essay?" For example, do you want the admissions committee to understand your choice of major and career in relation to your family background, or do you want to share your passion for your chosen field and your desire to achieve excellence in it? Whichever theme you come up with, this has to be unique to you as an applicant and should be related to your personal background, choice of major, and choice of career. The more unique a theme is, the more interesting the essay will be. In this sense, you can capitalize on personal facts you believe are noteworthy of exposition.